Showing posts with label 2nd semester. Show all posts
Showing posts with label 2nd semester. Show all posts

Monday, 16 June 2014

Syllabus Of BIOCHEMISTRY OF METABOLISM



BIOCHEMISTRY OF METABOLISM
2(2-0)
THEORY
Introduction of metabolism, Glycolysis, regulation, and energy production, Kreb‟s cycle, regulation and energy production, Pentose phosphate shunt, Glucoronic acid pathway, Glucogensis, glycogensis, glycogenolysis, gluconeogensis, Metabolism of fructose, galactose and lactose, Introduction to protein metabolism and plasma amino acidsSynthesis of non-essential amino acids, Fate of ammonia and keto-acids, Urea cycle and its importance, glutathione and creatinine formation, Catabolism of non-essential amino acids,Introduction to lipid metabolism, Beta-oxidation of even chained-fatty acids, Beta-oxidation of odd-chained fatty acids, Omega-oxidation of fats, Alpha-oxidation of fats, Oxidation of respiratory chain, Biosynthesis of fatty acids, Biosynthesis of triglycerides,Biosynthesis of triglycerides, Biosynthesis of prostaglandins, Biosynthesis of cholesterol, Factors affecting cholesterol level in plasma,Transportation of lipids, Role of adipose tissue in fat metabolism, Ketogensis and use of ketone bodies, Metabolism of bile salts and bile acids, Intermediary metabolism of carbohydrates, fats and proteins,
23
Bioenergetics, Introduction to fermentation, Use of agro-industrial wastes for production of antibiotics, enzymes and steroids,

BOOKS RECOMMENDED

1. Ahmad Mushtaq, A. (2003). essential of medical biochemistry, Vol !, 7th Ed. Ilmi book house urdu bazaar, Lahore
2. Murrary, R. K, D. K. Granner, P.A Mayes and V.W Redwell. (2000). Harper‟s Biochemistry, 25th Ed. Appleton & Lange Inc. USA
3. Stryer, L. 1995. Biochemistry. W. H. Freemen Pub. Co. USA.
4. Nelson, D. L & M M. Cox (2000). Leheninger Principles of Biochemistry. 3rd Ed., Livingston Pub, Inc, USA.

5. Brown, T. A. (2001). Gene cloning and DNA analysis: An Introduction. 4th Ed. Blackwell science Ltd., U.K.

Saturday, 7 June 2014

Subjects Of 2nd semester

Subjects Of 2nd semester

COURSE NO.
COURSE TITLE
Contact Hours

Theory                  Practical


ANAT
Comparative Anatomy
1
6
ANAT
Systemic Veterinary Histology
1
4
MICRO
General Veterinary Microbiology
2
2
PHYSIOL
Physiology of Digestion and Lactation
2
2
BIOCHEM
Biochemistry of Metabolism
2
0
ABG
Introduction to Animal Breeding and Genetics
3
2
AN
Principles of Animal Nutrition
2
2
SS
Pakistan Studies
1
0
Total
14
18

Wednesday, 1 May 2013

Lecture 1 Physiology 2nd Semester


 Introduction To Gastrointestinal Physiology

n  DIGESTIVE SYSTEM
n  In simple terms, the digestive system is a portal for nutrients to gain access to the circulatory system.
   Foodstuffs are broken down to very simple molecules.
   Resulting sugars, amino acids, fatty acids, etc. are then transported across the GI tract lining into blood.
   The specific foodstuffs animals are able to utilize is dependent on the type of digestive system they possess.
n  Three (3) basic types of digestive systems:
   Monogastric – simple stomach.
   Ruminant (cranial fermentor) – multi-compartmented stomach.
   Hind gut (caudal) fermentor – simple stomach, but very large and complex large intestine
Basic Functional Anatomy of the Digestive System

Monogastrics
n Organs of the Digestive System
– Monogastrics
n Mouth
   Mechanical breakdown of foodstuffs by chewing (reduces particle size, increases surface area for action of enzymes).
   Saliva added as a lubricant and, in some species, contains amylase to begin starch digestion.
Esophagus
   Tube connecting the mouth to the stomach.
n Stomach
   Enzymatic digestion of proteins begins.
   Foodstuffs reduced to liquid form.
Liver
   Center of metabolic activity in the body.
   Major role in digestive process is to provide bile salts to small intestine (needed for digestion and absorption of fats).
n Pancreas
   Provides a potent mixture of digestive enzymes to the small intestine to help in digestion of fats, carbohydrates, and proteins.
Small Intestine
   3 sections – duodenum, jejunum, ileum
   Site of final stages of chemical enzymatic digestion.
   Where almost all nutrients are absorbed.

n Large Intestine
   3 sections – cecum, colon, rectum
   Site of water absorption from G.I. tract.
   Bacterial fermentation occurs (production and absorption of volatile fatty acids).
P  Somewhat limited in monogastrics
   Feces formed.
Specialized Organs in Poultry
n Beak
   No lips, no teeth, and no chewing.
Crop
   Out-pocketing of the esophagus that provides storage for consumed food.
   Foodstuffs moistened and softened (little if any digestion).

n Proventriculus
   Glandular stomach where the first significant amount of digestive juices are added.
n Gizzard
  A muscular organ used to grind and break up food.
   May contain grit (small stones) eaten by animal.

n Cloaca
   Common chamber into which the digestive, urinary, and reproductive tracts open.
   When fecal material is excreted, the cloaca folds back at the vent allowing the rectal opening of the large intestine to push out, closing the reproductive tract opening.

Basic Functional Anatomy of the Digestive System

Ruminants

«  Mouth, esophagus, liver, pancreas, gall bladder, small intestine, and large intestine have functions similar to monogastrics.
«  Ruminants produce prodigious quantities of saliva. Published estimates for adult cows are in the range of 100 to 150 liters of saliva per day! Aside from its normal lubricating qualities, saliva serves at least two very important functions in the ruminant:
«  provision of fluid for the fermentation vat
«  alkaline buffering - saliva is rich in bicarbonate, which buffers the large quanitity of acid produced in the rumen and is probably critical for maintainance of rumen pH.
« Stomach
«  Structure and function of the stomach is the major difference between monogastrics and ruminants.
Multi-compartmented stomach – rumen, reticulum, omasum, abomasum
n  Rumen:
   Large, anaerobic fermentation vat.
n  Rumen (continued):
  Houses microorganisms.
n  Protozoa – 100,000 per gram of rumen fluid.
n  Bacteria/fungi – 100 million per gram of rumen fluid.
  Functions of microorganisms.
n  Digest roughages to make Volatile Fatty Acids (VFA’s), make microbial protein, and make vitamins K and B-complex.
   VFA’s absorbed in rumen.
   Lined with millions of papillae (short projections on wall of rumen) needed for absorption.
   “Shag carpet” appearanc
n  Rumen saturated with gases and in constant motion.
n  Contractions occur at a rate of 1-3 per minute.
   Serve to mix contents, aid in eructation of gases, and move fluid and fermented feedstuffs into the omasum.
n  Rumination:
   Ruminants are well known for “cud chewing”.
   Rumination involves:
n  Bolus of previously eaten foodstuff carried back into the mouth by reverse peristalsis.
n  Fluid in bolus is squeezed out with the tongue and reswallowed.
n  Bolus is rechewed and reswallowed.
   Rumination may occupy about 1/3 of a ruminant’s day
n  Eructation (belching):
   Fermentation of foodstuffs in the rumen generates enormous quantities of gas.
n  30-50 liters per hour in adult cattle.
n  5-7 liters per hour in adult sheep or goats.
   Belching is how ruminants get rid of fermentation gases:
n  Anything that causes a hindrance to belching can be life threatening.
n  Bloating can result in death from asphyxiation.
n  Reticulum:
   Contains microorganisms (like the rumen).
   Provides additional area for fermentation.
   As fermentation by microorganisms proceed and feedstuffs are digested, smaller and more dense material is pushed into the reticulum (from which it along with microbe-laden liquid is ejected into the omasum).
   Lining has a honeycomb structure.
n  Catches and holds hardware consumed by animal.
n  Hardware can be removed with rumen magnate.
n  Omasum:
   A heavy, hard organ with a lining that has many folds (leaves).
  Function not well understood.
   Believed to produce a grinding action on foodstuffs.
   May absorb residual VFA’s and bicarbonate.
n  Abomasum:
   The true, glandular stomach.
n  Secretes acids and functions very similarly to monogastric stomach.
   Unique feature is that it secretes lysozyme.
n  Enzyme that efficiently breaks down bacterial cell walls.
n  Needed to break down the large quantities of bacteria that pass from the rumen.
n Basic Functional Anatomy of the Digestive System

Hind Gut Fermentors

 Organs of the Digestive System
– Hind Gut Fermentors –
«  Mouth, esophagus, stomach, liver, pancreas, gall bladder, and small intestine have similar functions as compared to monogastrics.
n  Large Intestine
   Major difference between monogastrics and hind gut fermentors is the large intestine
   Large intestine is exceptionally large and complex compared to monogastrics and ruminants.
n  The large intestine of hind gut fermentors is analogous to the rumen in ruminants.
   Large, anaerobic fermentation vat.
   Microbes digest structural carbohydrates (cellulose, hemicellulose) and soluble carbohydrates that escape digestion in small intestine to VFA’s.
n  VFA’s absorbed from large intestine and utilized by the animal.
   Microbial protein produced in large intestine is wasted (only very limited absorption from large intestine).
n Summary
n  There are three (3) basic types of digestive systems in farm animal species.
   Monogastric
   Ruminant (cranial fermentor)
   Hind gut (caudal fermentor)
   The type of digestive system influences the dietary foodstuffs the animal can effectively utilize.




















Twitter Delicious Facebook Digg Stumbleupon Favorites More

 
Design by Free WordPress Themes | Bloggerized by Lasantha - Premium Blogger Themes | Bluehost Review